1620323-33-2Relevant academic research and scientific papers
Enantioselective synthesis of α,α-difluoro-β-lactams using amino alcohol ligands
Tarui, Atsushi,Ikebata, Takeshi,Sato, Kazuyuki,Omote, Masaaki,Ando, Akira
, p. 6484 - 6489 (2014)
A practical and highly enantioselective Reformatsky reaction of ethyl bromodifluoroacetate with imines using a cheap and commercially available amino alcohol ligand is described. A variety of α,α-difluoro-β- lactams were obtained in up to 74% yield with high enantioselectivity in excess of 99% ee. The use of ethyl bromodifluoroacetate provides for ease of operation because of the inherent chemical stability of this reagent. the Partner Organisations 2014.
