162042-44-6

Basic information

• Product Name: L371,257
• Synonyms: L371,257;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
• CAS NO: 162042-44-6
• Molecular Formula: C28H33N3O6
• Molecular Weight: 507.584
• Mol File: 162042-44-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 728.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.282±0.06 g/cm3(Predicted)
• Storage Temp.: Store at RT
• PKA: 0.73±0.20(Predicted)
• CAS DataBase Reference: L371,257(CAS DataBase Reference)
• NIST Chemistry Reference: L371,257(162042-44-6)
• EPA Substance Registry System: L371,257(162042-44-6)

Safety Data

• Hazardous Substances Data: 162042-44-6(Hazardous Substances Data)

Usage

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

Upstream product

• 108-24-7 acetic anhydride 
• 162042-41-3 4-{3-Methoxy-4-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-carbonyl]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 162045-31-0 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride 
• 162045-30-9 1-(N-t-butyloxy-carbonyl-4-piperidinyl)-4H-3,1-benzoxazin-2(1H)-one 
• 162045-37-6 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester 
• 162045-38-7 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxy-benzoic acid 
• 162045-36-5 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-hydroxybenzoic acid methyl ester 
• 162045-29-6 1-(tert-Butoxycarbonyl)-4-[(2-hydroxymethylphenyl)amino]piperidine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 5344-90-1 2-Aminobenzyl alcohol 

Relevant articles and documents

1--2-methoxybenzoyl>piperidin-4-yl>-4H-3,1-benzoxazin-2(1H)-one (L-371,257): A New, Orally Bioavailable, Non-Peptide Oxytocin Antagonist

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