162046-65-3Relevant articles and documents
S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling
Wang, Xuefeng,Yang, Min,Ye, Shengqing,Kuang, Yunyan,Wu, Jie
, p. 6437 - 6441 (2021/05/19)
Sulfuric chloride is used as the source of the -SO2- group in a palladium-catalyzed three-component synthesis of sulfonamides. Suzuki-Miyaura coupling between the in situ generated sulfamoyl chlorides and boronic acids gives rise to diverse sulfonamides in moderate to high yields with excellent reaction selectivity. Although this transformation is not workable for primary amines or anilines, the results show high functional group tolerance. With the solving of the desulfonylation problem and utilization of cheap and easily accessible sulfuric chloride as the source of sulfur dioxide, redox-neutral three-component synthesis of sulfonamides is first achieved. This journal is
phenyl-propionamide derivative, preparation method and application thereof in medicine
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Paragraph 0231; 0233; 0234; 0235; 0236, (2017/10/05)
The invention relates to a phenyl-propionamide derivative, and a preparation method and application thereof in medicine, in particular to a phenyl-propionamide derivative shown in a general formula (I), a preparation method thereof and a medicine composition comprising the derivative, a use as a k opioid receptor (KOR receptor) agonist, and an application in preparing drugs for treating and/or preventing pains and pain-related diseases. The definition of various substituent groups of the general formula (I) is same with the definition in the description. The formula is shown in the description.