1620488-22-3Relevant academic research and scientific papers
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency
Turlington, Mark,Noetzel, Meredith J.,Bridges, Thomas M.,Vinson, Paige N.,Steckler, Thomas,Lavreysen, Hilde,Mackie, Claire,Bartolomé-Nebreda, José M.,Conde-Ceide, Susana,Tong, Han Min,Macdonald, Gregor J.,Daniels, J. Scott,Jones, Carrie K.,Niswender, Colleen M.,Conn, P. Jeffrey,Lindsley, Craig W.,Stauffer, Shaun R.
, p. 3641 - 3646 (2014/07/22)
We report the optimization of a series of novel metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) from a 5,6-bicyclic class of dihydropyrazolo[1,5-a]pyridin-4(5H)-ones containing a phenoxymethyl linker. Studies foc
