162049-16-3

Upstream product

• 162049-15-2 4-(4-Amino-butylamino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidin-2-one 
• 162049-17-4 6-(p-bromobenzoylamino)caproic acid N-hydroxysuccinimide ester 
• 6979-97-1 3',5'-diacetylthymidine 
• 80991-41-9 1-(3,5-Di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 
• 50-89-5 thymidine 
• 78121-39-8 ε-(p-bromobenzoylamindo)caproic acid 

Relevant academic research and scientific papers

Synthesis of 5-methyl-2'-O-deoxycytidine analogs to determine monoclonal antibody specificity in the recognition of the 6-(p-bromobenzoylamino) caproyl radical

Eight new p-bromobenzoyl derivatives of 5-methyl-2'-O-deoxycytidine analogs, substituted at the 4-position, were synthesized. The best conditions for obtaining 5-methyl-4-N-aminoalkyl-2'-O-deoxycytidine from 3',5'-di-O- acetyl-4-(1,2,4-triazol-1-yl)-2'-O-deoxythymidine were studied. The nucleoside analogs were used to identify the fragment of the 6-(p- bromobenzoylamino)caproyl radical that binds to the monoclonal antibody obtained against it and to define an affinity scale of monoclonal antibody against them.

Introduction of an immunochemical label in a cytidine analogue

A new immunochemical label was synthesized and used as an artificial hapten to obtain a monoclonal antibody that specifically recognizes it. The new cytidine analogues, 5-methyl-4-N-{4-[6-(p-bromobenzoylamido)caproylamido]but-1-yl }-2'-de oxycytidine and