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Usage

Uses

Used in Pharmaceutical Research:
2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D is used as a research compound for studying the induction of goblet cell secretion in rats. This application helps in understanding the role of histamine and its derivatives in the regulation of mucus production and secretion, which is crucial for various respiratory and gastrointestinal conditions.
Used in Cellular and Molecular Biology:
In the field of cellular and molecular biology, 2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D is used as a tool to investigate the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells. This research contributes to the understanding of the complex interactions between histamine receptors, inflammatory mediators, and vascular function, which is essential for developing targeted therapies for various inflammatory and vascular diseases.
Used in Application Industry:
2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D is used as a chemical intermediate for the synthesis of other compounds with potential pharmaceutical applications. Its unique structure and properties make it a valuable building block in the development of new drugs targeting histamine receptors and related pathways.

Biochem/physiol Actions

2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be the most potent and selective H1 histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H2, H3, and other neurotransmitter receptors. It showed better potency at the guinea pig H1 histamine receptor than at the human H1 histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H1:H2), > 64 (H1:H3), 1000 (H1:M3), 105 (H1: a1), 708 (H1:β1), and 71 (H1:5HT2A). 2-((3-Trifluoromethyl)phenyl)histamine dimaleate does not cross the blood-brain barrier.