1620495-98-8

Basic information

• Product Name: 1-(2-(2,4-dichlorobenzoyl)pyrrolidin-1-yl)ethanone
• CAS NO: 1620495-98-8
• Molecular Weight: 286.158
• Mol File: 1620495-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-(2,4-dichlorobenzoyl)pyrrolidin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(2,4-dichlorobenzoyl)pyrrolidin-1-yl)ethanone(1620495-98-8)
• EPA Substance Registry System: 1-(2-(2,4-dichlorobenzoyl)pyrrolidin-1-yl)ethanone(1620495-98-8)

Safety Data

• Hazardous Substances Data: 1620495-98-8(Hazardous Substances Data)

Upstream product

• 70935-35-2 1-acetyl-pyrrolidine-2-carbonyl chloride 
• 541-73-1 1,3-Dichlorobenzene 
• 1074-79-9 N-Acetyl-DL-prolin 
• 609-36-9 rac-Pro-OH 

Downstream Products

• 1620495-87-5 (5-amino-3-phenyl-1,2,4-triazin-6-yl)(2-(6-chlorobenzo[d]isoxazol-3-yl)pyrrolidin-1-yl)methanone 

Relevant articles and documents

Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents

A series of novel (5-amino-3-substituted-1, 2, 4-triazin-6-yl) (2-(6-halo-substituted benzo[d]isoxazol-3-yl) pyrrolidin-1-yl) methanone 5a-5r was synthesized. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test and neurotoxicity was evaluated by the rotorod test. The MES test showed that (5-amino-3-phenyl-1, 2, 4-triazin-6-yl)(2-(6-fluorobenzo[d]isoxazol-3-yl) pyrrolidin-1-yl) methanone 5c was found to be the most potent compound with ED50 value of 6.20mg/kg (oral/rat) and a protective index (PI=ED50/TD50) value of >48.38, which was much higher than the PI of the reference drug phenytoin. To explain the possible mechanism of action of selected derivatives 5b, 5c, 5i and 5o, their influence on sodium channel was evaluated in vitro.