16205-59-7

Upstream product

• 115459-50-2 2,3,5-Tri-O-benzoyl-D-ribofuranose 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 

Downstream Products

• 140186-54-5 C₃₁H₂₅NO₇S 
• 73990-92-8 7-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)lumazin 
• 73978-61-7 7-Hydroxy-1,3-bis(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)lumazin 
• 73978-57-1 7-Hydroxy-6-phenyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)lumazin 
• 79378-84-0 4-amino-2,6-diphenyl-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone 
• 79378-82-8 4-amino-2-phenyl-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone 
• 35867-79-9 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone 
• 457067-55-9 phenyl 2,3,5-tri-O-benzoyl-1-thio-β-D-ribofuranoside 
• 1748-04-5 tribenzoyl uridine 
• 88999-59-1 (3aR,5R,5aS,8aS,8bR)-5-((((2S,3R,4R,5R)-3,4-Bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-yl)oxy)methyl)-2,2,7,7-tetramethyltetrahydro-5H-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran 
• 140186-55-6 1,2:5,6-di-O-isopropylidene-3-O-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-α-D-glucofuranoside 
• 140186-66-9 methyl (2,3,5-tri-O-benzyl-α-D-ribofuranosyl)-(1→5)-2,3-O-isopropylidene-β-D-ribofuranoside 
• 96689-78-0 2-pyridyl 2,3,5-tri-O-benzyl-1-thio-β-D-ribofuranoside 
• 113575-02-3 1,2--α-D-ribofuranose 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS USED IN ASSESSING MONO-PARP ACTIVITY

Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

3-methyl uridine and 4-methyl cytidine nucleoside compound, synthetic method and its pharmaceutical use

The invention discloses a 3-methyluridine and 4-methylcytidine nucleosides compound and a synthesis method and pharmaceutical application thereof, belonging to the field of medicinal chemistry. The compound has a structural formula as shown in the specification. The compound has the effects of simultaneously modifying sugar rings and basic groups, increasing the activity of the compound and reducing the toxicity, provides a good application prospect for development of like medicines and can be applied to preparation of anti-HBV (Hepatitis B virus) medicines. The synthesis method is simple and feasible and provides conditions for mass synthesis of the compound.

Appel-reagent-mediated transformation of glycosyl hemiacetal derivatives into thioglycosides and glycosyl thiols

A series of glycosyl hemiacetal derivatives have been transformed into thioglycosides and glycosyl thiols in a one-pot two-step reaction sequence mediated by Appel reagent (carbon tetrabromide and triphenylphosphine). 1,2-trans-Thioglycosides and β-glycosyl thiol derivatives were stereoselectively formed by the reaction of the in situ generated glycosyl bromides with thiols and sodium carbonotrithioate. The reaction conditions are reasonably simple and yields were very good.