162051-22-1

Basic information

• Product Name: 3-[2-(dimethylamino)ethyl]-5,5-diphenyldihydrofuran-2(3H)-one
• CAS NO: 162051-22-1
• Molecular Formula: C₂₀H₂₃NO₂
• Molecular Weight: 309.4021
• Mol File: 162051-22-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 458.3°C at 760 mmHg
• Flash Point: 155°C
• Density: 1.101g/cm³
• Vapor Pressure: 1.39E-08mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 3-[2-(dimethylamino)ethyl]-5,5-diphenyldihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(dimethylamino)ethyl]-5,5-diphenyldihydrofuran-2(3H)-one(162051-22-1)
• EPA Substance Registry System: 3-[2-(dimethylamino)ethyl]-5,5-diphenyldihydrofuran-2(3H)-one(162051-22-1)

Safety Data

• Hazardous Substances Data: 162051-22-1(Hazardous Substances Data)

Upstream product

• 5429-29-8 1,3-diethyl 2-[2-(dimethylamino)ethyl]propanedioate 
• 882-59-7 1,1-diphenyloxirane 

Relevant articles and documents

Mechanism(s) of pharmacological action of an α-(aminoethyl)-γ-butyrolactone. In vivo studies in mice

This paper describes the synthesis of α-(dimethylaminoethyl)-γ,γ-diphenyl-γ-butyrolactone 4. The study of convulsions induced, on mice, by this compound could show the existence of antiGABAergic and cholinergic action components, but, unlike the homologous α-(dialkylaminomethyl)-γ-butyrolactones (with one -CH2- less on the aminoalkyl chain), no antiglycinergic component was detected. The effects of atropine on the aminolactone 4 induced convulsions (antagonism 5 mn and synergy 30 mn after atropine) could suggest an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the aminolactone 4.