1620517-46-5Relevant academic research and scientific papers
The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6- alkyl CXCR2 receptor antagonists
Porter, David W.,Bradley, Michelle,Brown, Zarin,Charlton, Steven J.,Cox, Brian,Hunt, Peter,Janus, Diana,Lewis, Sarah,Oakley, Paul,O'Connor, Des,Reilly, John,Smith, Nichola,Press, Neil J.
, p. 3285 - 3290 (2014/07/22)
A hit-to-lead optimisation programme was carried out on the Novartis archive screening hit, pyrimidine 2-((2,6-dichlorobenzyl)thio)-5-isocyano-6- phenylpyrimidin-4-ol 4, resulting in the discovery of CXCR2 receptor antagonist 2-((2,3-difluorobenzyl)thio)-
