1620523-76-3

Upstream product

• 1620523-73-0 1-tert-butyl 3-methyl (3S,5R)-5-[2,2-dimethyl-3-(2-methylanilino)propanoyl]piperidine-1,3-dicarboxylate 
• 1620523-72-9 1-tert-butyl 3-methyl (3S,5R)-5-(2,2-dimethyl-3-oxopropanoyl)piperidine-1,3-dicarboxylate 
• 1620523-70-7 C₁₈H₃₁NO₅ 
• 1620523-69-4 C₁₃H₂₁NO₅ 
• 1620523-68-3 1-tert-butyl 3-methyl (3S,5R)-5-hydroxymethylpiperidine-1,3-dicarboxylate 
• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 
• 1620523-71-8 1-tert-butyl 3-methyl (3S,5R)-5-(2,2-dimethylbut-3-enoyl)piperidine-1,3-dicarboxylate 
• 1620523-75-2 1-tert-butyl 3-methyl (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]piperidine-1,3-dicarboxylate 

Downstream Products

• 1620523-79-6 (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-N-[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]piperidine-3-carboxamide fumarate 
• 1620523-77-4 tert-butyl (3S,5S)-3-[3,3-dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 

Relevant academic research and scientific papers

An efficient synthesis of (3S,5S)-5-[3,3-dimethyl-1-(o-tolyl)-6-OXO-2H- pyridin-4-YL]- piperidine-3-carboxamide as potent renin inhibitor

We report synthesis and biological evaluation of (3S,5S)-5-[3,3- dimethyl-1-(o-tolyl)-6-oxo-2H-pyridin-4-yl]piperidine-3-carboxamide as renin inhibitor. This effective synthetic route involves a zinc mediated Barbier reaction and an intramolecular Horner-Wadsworth-Emmons reaction of sterically hindered ketone as key reactions. The prepared compound 4 exhibited both potent renin inhibitory activity and significant in vivo efficacy in furosemide pretreated cynomolgus monkeys.