1620558-20-4Relevant academic research and scientific papers
Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties
Yoon, Yeong Keng,Ali, Mohamed Ashraf,Wei, Ang Chee,Shirazi, Amir Nasrolahi,Parang, Keykavous,Choon, Tan Soo
, p. 448 - 454 (2014)
Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. Among the newly synthesized compounds, compound 4j displayed the best inhibitory activity for SIRT1 (IC50 = 54
