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CAS

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1620567-92-1

4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1620567-92-1 Structure

  • Basic information

    1. Product Name: 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine
    2. Synonyms: 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine
    3. CAS NO:1620567-92-1
    4. Molecular Formula:
    5. Molecular Weight: 306.318
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1620567-92-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine(1620567-92-1)
    11. EPA Substance Registry System: 4-(4-methylpiperazin-1-yl)-6-(3,5-difluorophenyl)-1,3,5-triazin-2-amine(1620567-92-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1620567-92-1(Hazardous Substances Data)

1620567-92-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1620567-92-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,0,5,6 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1620567-92:
(9*1)+(8*6)+(7*2)+(6*0)+(5*5)+(4*6)+(3*7)+(2*9)+(1*2)=161
161 % 10 = 1
So 1620567-92-1 is a valid CAS Registry Number.

1620567-92-1Upstream product

1620567-92-1Downstream Products

1620567-92-1Relevant articles and documents

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands

?azewska, Dorota,Wi?cek, Ma?gorzata,Ner, Joanna,Kamińska, Katarzyna,Kottke, Tim,Schwed, J. Stephan,Zygmunt, Ma?gorzata,Karcz, Tadeusz,Olejarz, Agnieszka,Kuder, Kamil,Latacz, Gniewomir,Grosicki, Marek,Sapa, Jacek,Karolak-Wojciechowska, Janina,Stark, Holger,Kie?-Kononowicz, Katarzyna

supporting information, p. 534 - 546 (2014/07/21)

A series of novel 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazine derivatives with different aryl substituents in the 6-position was designed, synthesized and evaluated for histamine H4 receptor (H4R) affinity in Sf9 cells expressing human H4R co-expressed with G-protein subunits. Triazine derivative 8 with a 6-(p-chlorophenyl) substituent showed the highest affinity with hH4R Ki value of 203 nM and was classified as an antagonist in cAMP accumulation assay. This compound, identified as a new lead structure, demonstrated also anti-inflammatory properties in preliminary studies in mice (carrageenan-induced edema test) and neither possessed significant antiproliferative activity, nor modulated CYP3A4 activity up to concentration of 25 μM. In order to discuss structure-activity relationships molecular modeling and docking studies were undertaken.

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