1620567-95-4

Basic information

• Product Name: 4-(4-methylpiperazin-1-yl)-6-(3,4-dimethylphenyl)-1,3,5-triazin-2-amine
• Synonyms: 4-(4-methylpiperazin-1-yl)-6-(3,4-dimethylphenyl)-1,3,5-triazin-2-amine
• CAS NO: 1620567-95-4
• Molecular Weight: 298.391
• Mol File: 1620567-95-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-methylpiperazin-1-yl)-6-(3,4-dimethylphenyl)-1,3,5-triazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylpiperazin-1-yl)-6-(3,4-dimethylphenyl)-1,3,5-triazin-2-amine(1620567-95-4)
• EPA Substance Registry System: 4-(4-methylpiperazin-1-yl)-6-(3,4-dimethylphenyl)-1,3,5-triazin-2-amine(1620567-95-4)

Safety Data

• Hazardous Substances Data: 1620567-95-4(Hazardous Substances Data)

Upstream product

• 38404-42-1 methyl 3,4-dimethylbenzoate 

Relevant articles and documents

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands

A series of novel 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazine derivatives with different aryl substituents in the 6-position was designed, synthesized and evaluated for histamine H4 receptor (H4R) affinity in Sf9 cells expressing human H4R co-expressed with G-protein subunits. Triazine derivative 8 with a 6-(p-chlorophenyl) substituent showed the highest affinity with hH4R Ki value of 203 nM and was classified as an antagonist in cAMP accumulation assay. This compound, identified as a new lead structure, demonstrated also anti-inflammatory properties in preliminary studies in mice (carrageenan-induced edema test) and neither possessed significant antiproliferative activity, nor modulated CYP3A4 activity up to concentration of 25 μM. In order to discuss structure-activity relationships molecular modeling and docking studies were undertaken.