1620631-21-1Relevant academic research and scientific papers
Novel compound from plasma-treated phloridzin and anti-obesity composition comprising the same as effective component
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Paragraph 0039-0042, (2019/08/16)
The present invention relates to a novel compound derived from plasma-treated phloridzin and an anti-obesity composition comprising the same as an effective component and, more specifically, to a diameric compound derived from phloridzin, which is newly formed by plasma-treating phloridzin (methylene-bis-phloridzin, diglucosyl-methylene-bis-phloridzin, and methylene-bis-phloretin), and to an anti-obesity composition comprising the same as an effective component. In particular, the compound derived from phloridzin, comapred to phloridzin, inhibits the activity of pancreatic lipase and enhances the effect of suppressing fat accumulation during differentiation of fat cells. In particular, the methylene-bis-phloretin of the present invention, a diameric body formed by phloretin using a methyl group, a form of which sugars are removed from phloridzin, has excellent inhibitory effect on fat accumlation as compared to phloretin, and thus may be beneficially used as a material for anti-obesity therapeutic agents or anti-obesity functional health foods.COPYRIGHT KIPO 2019
Facile formation of methylenebis(chalcone)s through unprecedented methylenation reaction. Application to antiparasitic and natural product synthesis
Thevenin, Marion,Mouray, Elisabeth,Grellier, Philippe,Dubois, Joelle
, p. 2986 - 2992 (2014/05/20)
The formation of methylenebis(chalcone)s has been discovered during deprotection with methoxymethyl groups from trihydroxychalcones. Studies on this methylenation reaction led to a mechanism hypothesis that was extended to other chalcones and to dihydrochalcone, acetophenone, benzophenone and flavone derivatives. This new method was applied to the rapid synthesis of natural product piperanduncin C. These original methylenebis compounds were also evaluated for their antiparasitic activity. Copyright
