1620667-61-9

Basic information

• Product Name: (2R,3S,4R,5S)-2-((p-toluidino)methyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol
• CAS NO: 1620667-61-9
• Molecular Weight: 269.298
• Mol File: 1620667-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S,4R,5S)-2-((p-toluidino)methyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4R,5S)-2-((p-toluidino)methyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol(1620667-61-9)
• EPA Substance Registry System: (2R,3S,4R,5S)-2-((p-toluidino)methyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol(1620667-61-9)

Safety Data

• Hazardous Substances Data: 1620667-61-9(Hazardous Substances Data)

Upstream product

• 59-23-4 D-Galactose 
• 106-49-0 p-toluidine 

Relevant articles and documents

Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.

MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5'-triphosphate (GTP) in the first step of molybdopterin biosynthesis. In this paper, we provide additional characterization of the MoaA reaction product, describe the use of 2′-chloroGTP to trap the GTP C3′ radical, generated by hydrogen atom transfer to the 5′-deoxyadenosyl radical, and the use of 2′-deoxyGTP to block a late step in the reaction sequence. These probes, coupled with the previously reported trapping of an intermediate in which C3′ of the ribose is linked to C8 of the purine, allow us to propose a plausible mechanism for the MoaA-catalyzed reaction.