1620682-50-9Relevant academic research and scientific papers
Palladium(0)-catalyzed intramolecular decarboxylative allylation of ortho nitrobenzoic esters
Hossian, Asik,Singha, Shantanu,Jana, Ranjan
supporting information, p. 3934 - 3937 (2014/08/18)
A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2-sp3 cross-coupling approach which requires air and moisture sensitive preformed organometallic reagents, we provide an alternative route to the synthesis of ortho-allyl nitroarenes from the corresponding ortho-nitrobenzoic acid derivatives. The reaction proceeds through a mechanistically distinct decarboxylative metalation pathway. A cooperative reactivity of palladium and silver is crucial for the reaction outcome.
