162070-34-0 Usage
General Description
"(5R,8S,10R)-2-Chloro-6-methyl-8-(1H-imidazol-1-ylmethyl)ergoline" is a chemical compound that belongs to the ergoline class of alkaloids. It is a derivative of ergoline, a chemical compound commonly found in fungi and used as a precursor in the synthesis of psychedelic drugs. The compound has a chlorine atom at the 2-position and a methyl group at the 6-position of the ergoline ring. Additionally, it contains an imidazole ring attached to the 8-position, which gives it unique pharmacological properties. The chemical is of interest because of its potential medical applications, particularly in the treatment of neurological and psychiatric disorders, as well as its potential use as a research tool in neuroscience. Further research and studies are needed to fully understand its biological activity and potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 162070-34-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,0,7 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 162070-34:
(8*1)+(7*6)+(6*2)+(5*0)+(4*7)+(3*0)+(2*3)+(1*4)=100
100 % 10 = 0
So 162070-34-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H21ClN4/c1-23-9-12(10-24-6-5-21-11-24)7-14-13-3-2-4-16-18(13)15(8-17(14)23)19(20)22-16/h2-6,11-12,14,17,22H,7-10H2,1H3/t12-,14?,17+/m0/s1
162070-34-0Relevant articles and documents
Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity
Ohno,Adachi,Koumori,Mizukoshi,Nagasaka,Ichihara,Kato -
, p. 1463 - 1473 (2007/10/02)
A series of new (5R,8R,10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats with unilateral 6- hydroxydopamine-induced lesions of the substantia nigra. (5R,8R,10R)-6- Alkyl-8-ergolinemethanols, prepared from the corresponding ergolinecarboxylates, were converted to the tosylates, which were treated with various five-membered heterocycles containing nitrogen atoms to afford the new ergolines. (5R,8R,10R)-8-(1,2,4-Triazol-1-ylmethyl)-6-methylergoline (4s, maleate: BAM-1110) exhibited potent dopaminergic activity, about 18- fold greater than that of bromocriptine mesylate. (5R,8R,10R)-8-(1,2,4- Triazol-1-ylmethyl)-6-propylergoline (8b, fumarate: BAM-1602) showed extremely potent dopaminergic activity, being about 220 and 1.15 times more active than bromocriptine mesylate and pergolide mesylate, respectively. Several compounds exhibited potent antihypertensive activity. Structure- activity relationships for antihypertensive and dopaminergic activities are discussed.
