1620809-10-0Relevant articles and documents
Synthesis and glycosidase inhibition study of 2-C-hydroxymethyl- and 6-C-hydroxymethyl-branched piperidines from D-glucose using ene-yne metathesis as a key step
Mallick, Asadulla,Vankar, Yashwant D.
, p. 4155 - 4161 (2014/07/08)
Two polyhydroxylated piperidine-based 2-C-hydroxymethyl-branched analogues of L-1-deoxyallonojirimycin (L-allo-DNJ) were synthesized from readily available 1,2:5,6-di-O-isopropylidene-α-glucofuranose through an ene-yne metathesis as the key step. The glycosidase inhibition activity of these compounds against some commercially available enzymes was examined, and the analogues were found to be very selective glycosidase inhibitors at concentrations in the range of 21-44 μM. Piperidine-based 2-C-hydroxymethyl-branched analogues of L-1-deoxyallonojirimycin (L-allo-DNJ) were synthesized from readily available D-glucose by using an ene-yne metathesis as the key step; PG = protecting group. The glycosidase inhibition activity of these compounds was studied and found to be active and very selective. Copyright