1620816-66-1Relevant articles and documents
Palladium-catalyzed direct C7-arylation of substituted indazoles
Naas, Mohammed,El Kazzouli, Sa?d,Essassi, El Mokhtar,Bousmina, Mosto,Guillaumet, Gérald
, p. 7286 - 7293 (2014/09/16)
A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K 2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/ arylation procedure leading to C3,C7-diarylated indazoles has been developed.