1620823-63-3Relevant academic research and scientific papers
Regiospecific synthesis of 2-halo-3-(2'-glucalyl)benzo[ b ]thiophenes
Kinfe, Henok H.,Makolo, Felix L.,Adokoh, Christian K.
, p. 7718 - 7722 (2014/09/16)
A regiospecific synthetic strategy for the synthesis of 2-chloro-3-substituted benzo[b]thiophenes is developed via a dichlorocarbene insertion and sigmatropic rearrangement of an in situ generated ylide. The current protocol provides a reversed regiochemistry to the commonly employed electrophilic cyclization reaction for the synthesis of benzo[b]thiophenes and access to their hitherto under-represented chlorinated derivatives.
