162089-64-7

Upstream product

• 349487-57-6 Acetic acid (1S,8aS)-3-hydroxy-7-methyl-3,5,8,8a-tetrahydro-1H-isochromen-1-ylmethyl ester 
• 162089-63-6 2-[(S)-6-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethanol 
• 199801-72-4 2,2,2-Trichloro-acetimidic acid 2-[(S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-cyclohex-3-en-(Z)-ylidene]-ethyl ester 

Downstream Products

• 162089-65-8 1-Benzyl-3-[(1R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-1-vinyl-cyclohex-3-enyl]-urea 
• 222983-15-5 2,2,2-Trichloro-N-[(1R,2S,4S,5R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,5-dihydroxy-4-methyl-1-vinyl-cyclohexyl]-acetamide 
• 253674-42-9 2,2,2-Trichloro-N-[(1R,2S,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 674793-26-1 (1R,4S,5R)-5-Amino-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-vinyl-cyclohex-2-enol 
• 457643-80-0 2,2,2-Trichloro-N-[(1R,2S,5R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 674793-27-2 Trichloro-acetic acid (1R,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohex-2-enyl ester 
• 674793-04-5 Acetic acid (1R,4S,6S,7R,8S,10S,11R)-11-acetoxy-8-(3-benzyl-ureido)-6-methoxy-11-methyl-3-oxo-2,5-dioxa-tricyclo[5.4.0.0^4,8]undec-10-yl ester 
• 674793-08-9 Acetic acid (1R,4S,6S,7R,8S,10S,11R)-11-acetoxy-8-(N'-acetyl-N',N''-dibenzyl-guanidino)-6-methoxy-11-methyl-3-oxo-2,5-dioxa-tricyclo[5.4.0.0^4,8]undec-10-yl ester 
• 271256-59-8 2,2,2-Trichloro-N-[(1R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-2-oxo-1-vinyl-cyclohex-3-enyl]-acetamide 
• 253674-39-4 2,2,2-Trichloro-N-[(1R,2R,6S)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-4-methyl-1-vinyl-cyclohex-3-enyl]-acetamide 
• 253674-44-1 N-[(1R,2S,3R,4S,6S)-2-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-formyl-6-methyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-2,2,2-trichloro-acetamide 
• 253674-43-0 N-[(1R,2S,3R,4S,6S)-2-Benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-6-methyl-3-vinyl-7-oxa-bicyclo[4.1.0]hept-3-yl]-2,2,2-trichloro-acetamide 
• 352670-32-7 (1S,4S,5R,6S,8S,9S)-9-(benzyloxy)-6-(dimethoxymethyl)-8-hydroxy-8-methyl-3-oxo-5-(2,2,2-trichloroacetamido)-2-oxabicyclo[3.3.1]nonan-4-yl acetate 
• 253674-50-9 Acetic acid (1S,4S,6R,7S,8R,9S,10S)-9-benzyloxy-8-(3-benzyl-ureido)-6-methoxy-10-methyl-3-oxo-2,5-dioxa-tricyclo[5.2.2.0^4,8]undec-10-yl ester 

Relevant academic research and scientific papers

Synthesis of a common key intermediate for (-)-tetrodotoxin and its analogs

A key intermediate for tetrodotoxin and its analogs such as (-)-5,11-dideoxytetrodotoxin was stereoselectively synthesized from a chiral starting material, levoglucosenone, via Diels-Alder reaction and the Overman rearrangement as key steps. The Overman r

Direct Preparation of Guanidine from Trichloroacetamide. A Potentially Important Method to (-)-Tetrodotoxin

Trichloroacetamides obtained via Overman sigmatropic rearrangement were converted into dibenzyl guanidines.The key step was conversion of carbodiimide intermediate into guanidine by scandium or ytterbium trifluoromethane-sulfonates.This method was a