1620988-84-2

Basic information

• Product Name: N-(3-methoxyphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine
• Synonyms: N-(3-methoxyphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine
• CAS NO: 1620988-84-2
• Molecular Weight: 299.376
• Mol File: 1620988-84-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-methoxyphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxyphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine(1620988-84-2)
• EPA Substance Registry System: N-(3-methoxyphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine(1620988-84-2)

Safety Data

• Hazardous Substances Data: 1620988-84-2(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 109-01-3 1-methyl-piperazine 
• 191728-86-6 2-chloro-N-(3-methoxyphenyl)pyrimidin-4-amine 

Relevant articles and documents

One-pot synthesis and antiproliferative activity of novel 2,4-diaminopyrimidine derivatives bearing piperidine and piperazine moieties

A series of novel 2,4-diaminopyrimidines containing piperidine and piperazine moieties were synthesized via an efficient one-pot methodology. The bioassay tests demonstrated that compounds 27 and 28 displayed much stronger antitumor activities against four human cancer cell lines (HepG2, A549, MDA-MB-231 and MCF-7) than positive control fluorouracil. Particularly, compound 28 showed a two-fold improvement compared to fluorouracil in inhibiting MDA-MB-231 and A549 cell proliferation with IC50 values of 7.46 and 12.78 μM, respectively. Further flow-activated cell sorting analysis revealed that the most promising compound 28 displayed a significant effect on G 2/M cell-cycle arrest in a dose-dependent manner in MDA-MB-231 cells.