162100-44-9

Basic information

• Product Name: 6-Chloro-5-methylindoline
• Synonyms: 6-Chloro-5-methylindoline;6-chloro-5-methyl-2,3-dihydro-1H-indole
• CAS NO: 162100-44-9
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.64
• Mol File: 162100-44-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-5-methylindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-methylindoline(162100-44-9)
• EPA Substance Registry System: 6-Chloro-5-methylindoline(162100-44-9)

Safety Data

• Hazardous Substances Data: 162100-44-9(Hazardous Substances Data)

Usage

General Description

6-Chloro-5-methylindoline is a chemical compound with the molecular formula C9H8ClN. It is an indoline derivative with a chlorine atom attached to the sixth carbon and a methyl group attached to the fifth carbon of the indoline ring. 6-Chloro-5-methylindoline is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various organic compounds. It possesses potential therapeutic properties and has been studied for its potential applications in the treatment of various diseases and disorders. Additionally, it has also been investigated for its potential use in organic synthesis and material science. Overall, 6-Chloro-5-methylindoline is a versatile chemical with promising applications in various fields.

Upstream product

• 755031-80-2 5-chloro-2-iodo-4-methylaniline 
• 95-74-9 3-chloro-p-toluidine 
• 71270-61-6 N-(3-chloro-4-methylphenyl)methanesulfonamide 
• 162100-42-7 6-chloro-5-methyl-1H-indole 

Downstream Products

• 1359945-91-7 C₂₂H₁₇ClF₃N₃O₂ 
• 162100-15-4 SB 215505 
• 181632-25-7 SB 242084 

Relevant articles and documents

Preparation method of indoline compound

The invention discloses a preparation of indoline compound expressed by the following general formula 1; the method successfully passes through for step reactions by applying iodine monochloride, acetenyl trimethyl silane and other reaction reagents, and obtains 6-chlorine-5-methyl indoline. Relative to the prior art, the synthetic method of the indoline derivative reduces the reaction step while improves the reaction yield. Moreover, the reaction condition is gentle, and easy to control; the method is good for large-scale industrial production.

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.