162100-83-6

Basic information

• Product Name: 6-Chloro-1H-indole-5-carboxylic acid methyl ester
• Synonyms: 6-Chloro-1H-indole-5-carboxylic acid methyl ester;Methyl 6-chloroindole-5-carboxylate
• CAS NO: 162100-83-6
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 210
• Mol File: 162100-83-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.381
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Chloro-1H-indole-5-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-1H-indole-5-carboxylic acid methyl ester(162100-83-6)
• EPA Substance Registry System: 6-Chloro-1H-indole-5-carboxylic acid methyl ester(162100-83-6)

Safety Data

• Hazardous Substances Data: 162100-83-6(Hazardous Substances Data)

Usage

General Description

6-Chloro-1H-indole-5-carboxylic acid methyl ester is a chemical compound with the molecular formula C11H9ClNO2. It belongs to the class of organic compounds known as indoles, which are characterized by a bicyclic structure that includes a benzene ring fused to a pyrrole ring. The "6-Chloro" part of its name indicates the presence of a chlorine atom at the 6th position in the indole structure. The presence of "5-carboxylic acid methyl ester" denotes a carboxylic ester functional group at the 5th position of the indole, which is a carboxylic acid derivative where one of its -OH groups has been replaced by an -OCH3 group. This chemical is used primarily in the fields of pharmaceuticals and research.

Upstream product

• 1036337-13-9 methyl 4-amino-2-chloro-5-((trimethylsilyl)ethynyl)benzoate 
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• 672292-98-7 4-acetylamino-2-chloro-5-trimethylsilanylethynyl-benzoic acid methyl ester 
• 309915-20-6 5-carboxymethyl-6-chloro-3-thiomethylindole 

Downstream Products

• 256935-86-1 6-chloro-indole-5-carboxylic acid 
• 1380284-61-6 [3-(2-tert-Butyl-pyrimidin-4-yl)-6-chloro-1H-indol-5-yl]-[4-(4-fluorobenzyl)-piperidin-1-yl]-methanone 
• 1380284-65-0 3-Acetyl-6-chloro-5-[4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-indole-1-carboxylic acid benzyl ester 
• 1380284-64-9 3-acetyl-6-chloro-1H-indol-5-yl[4-(4-fluorobenzyl)piperidin-1-yl]methanone 

Relevant articles and documents

SUBSTITUTED INDOLE/INDAZOLE-PYRIMIDINYL COMPOUNDS

The present disclosure provides indole/indazole-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein W, X, R1, R2,

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

METHODS TO SYNTHESIZE INDOLES AS PRECURSORS FOR PHARMACEUTICALS

The invention provides improved methods for the synthesis of indoles, especially useful for making indoles having an ester or amide group at C-5. The methods involve cyclization of a protected ortho-acetylene-substituted aniline derivative to produce an i