1621069-66-6

Basic information

• Product Name: O,O′-diethyl (2-fluorophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)acetamido)methylphosphonate
• Synonyms: O,O′-diethyl (2-fluorophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)acetamido)methylphosphonate
• CAS NO: 1621069-66-6
• Molecular Weight: 541.47
• Mol File: 1621069-66-6.mol

Chemical Properties

• CAS DataBase Reference: O,O′-diethyl (2-fluorophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)acetamido)methylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: O,O′-diethyl (2-fluorophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)acetamido)methylphosphonate(1621069-66-6)
• EPA Substance Registry System: O,O′-diethyl (2-fluorophenyl)(2-(1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yloxy)acetamido)methylphosphonate(1621069-66-6)

Safety Data

• Hazardous Substances Data: 1621069-66-6(Hazardous Substances Data)

Upstream product

• 120-80-9 benzene-1,2-diol 
• 85-44-9 phthalic anhydride 
• 72328-69-9 2-((1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy)acetic acid 
• 181259-90-5 α-O,O'-diethyl amino(2-fluorophenyl)methylphosphonate 
• 72-48-0 1,2-dihydroxy-9,10-anthracenedione 

Relevant articles and documents

Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety

A series of novel α-aminophosphonate derivatives containing an alizarin moiety (6-7) was designed and synthesized as antitumor agents. MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) assay results indicated that most compounds exhibited moderate to high inhibitory activity against KB, NCI-H460, HepG 2, A549, MGC-803, Hct-116, CNE and Hela tumor cell lines. The action mechanism of representative compounds 7h, 7j and 7n were investigated by fluorescence staining assays, flow cytometric analysis and real-time polymerase chain reaction (PCR) assays, which indicated that these compounds induced apoptosis and involved G1 phase arrest by increasing the production of intracellular Ca2+ and reactive oxygen species (ROS) and affecting associated enzymes and genes. The results demonstrated that these compounds may induce apoptosis through a mitochondrion-dependent pathway.