1621069-71-3

Upstream product

• 120-80-9 benzene-1,2-diol 
• 85-44-9 phthalic anhydride 
• 112579-84-7 diethyl [amino(4-methylphenyl)methyl]phosphonate 
• 72328-69-9 2-((1-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy)acetic acid 
• 72-48-0 1,2-dihydroxy-9,10-anthracenedione 

Relevant academic research and scientific papers

Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety

A series of novel α-aminophosphonate derivatives containing an alizarin moiety (6-7) was designed and synthesized as antitumor agents. MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) assay results indicated that most compounds exhibited moderate to high inhibitory activity against KB, NCI-H460, HepG 2, A549, MGC-803, Hct-116, CNE and Hela tumor cell lines. The action mechanism of representative compounds 7h, 7j and 7n were investigated by fluorescence staining assays, flow cytometric analysis and real-time polymerase chain reaction (PCR) assays, which indicated that these compounds induced apoptosis and involved G1 phase arrest by increasing the production of intracellular Ca2+ and reactive oxygen species (ROS) and affecting associated enzymes and genes. The results demonstrated that these compounds may induce apoptosis through a mitochondrion-dependent pathway.