162107-48-4Relevant articles and documents
Synthesis of furanomycin derivatives by gold-catalyzed cycloisomerization of α-hydroxyallenes
Erdsack, Joerg,Krause, Norbert
, p. 3741 - 3750 (2007)
The novel furanomycin analogues 8 and 17 were synthesized as mixture of two diastereomers using the gold-catalyzed cycloisomerization of α-hydroxyallenes as the key step. Compared to the traditional use of stoichiometric amounts of silver salts, gold catalysis is much more efficient for the cyclization of highly functionalized substrates. Georg Thieme Verlag Stuttgart.
Synthesis of a Novel Rhizobitoxine-Like Triazole-Containing Amino Acid
Boibessot, Thibaut,Bénimèlis, David,Jean, Marion,Benfodda, Zohra,Meffre, Patrick
supporting information, p. 2685 - 2688 (2016/11/30)
The synthesis of the four stereoisomers of a new 1,2,3-triazole analogue of rhizobitoxine from serine is described. The key step is a Huisgen 1,3-dipolar cycloaddition on an ethynylglycine synthon.
INDOLE COMPOUND AS INHIBITOR OF NECROSIS
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Paragraph 0191; 0192; 0193; 0203; 0204, (2016/08/17)
The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.
A macrocyclic approach to tetracycline natural products. Investigation of transannular alkylations and Michael additions
Wzorek, Joseph S.,Kn?pfel, Thomas F.,Sapountzis, Ioannis,Evans, David A.
supporting information, p. 5840 - 5843 (2013/02/25)
A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.