162107-50-8Relevant articles and documents
Synthesis of optically active β,γ-alkynylglycine derivatives
Meffre, Patrick,Gauzy, Laurence,Branquet, Eric,Durand, Philippe,Le Goffic, Francois
, p. 11215 - 11238 (2007/10/03)
Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected β,γ-alkynylglycine derivatives described have ee greater than 90%.