1621082-58-3

Upstream product

• 1666-13-3 diphenyl diselenide 
• 1621082-55-0 (S)-methyl 2-methyl-3-oxo-2-(phenylselanyl)-5-(4-(prop-1-en-2-yl)cyclohex-1-enyl)pentanoate 
• 105-45-3 acetoacetic acid methyl ester 
• 1621082-53-8 (S)-methyl 3-oxo-5-(4-(prop-1-en-2-yl)cyclohex-1-enyl)pentanoate 
• 1621082-54-9 (S)-methyl 2-methyl-3-oxo-5-(4-(prop-1-en-2-yl)cyclohex-1-enyl)pentanoate 

Relevant academic research and scientific papers

Enantiospecific synthesis and cytotoxicity evaluation of ligudentatol: A programmed aromatization approach to the 2,3,4-trisubstituted phenolic motif via visible-light-mediated group transfer radical cyclization

A facile enantiospecific approach to (+)-ligudentatol (1) and (-)-ligudentatol (ent-1) is reported. The approach features the construction of a trisubstituted phenolic motif fused to a chiral aliphatic ring by a sequence of visible-light-mediated radical seleno transfer cyclization, bromination, concomitant selenoxide elimination-dehydrobromination, and demethoxycarbonylation, namely, a programmed aromatization. Biological evaluation of the enantiomers of ligudentatol obtained by the present route revealed for the first time their cytotoxicity towards various cancer cell lines. Light gifts: A facile enantiospecific approach to (+)-ligudentatol (1) and (-)-ligudentatol (ent-1) is reported. The approach features the construction of a trisubstituted phenolic motif fused to a chiral aliphatic ring by a sequence of visible-light-mediated seleno transfer radical cyclization, bromination, concomitant selenoxide elimination-dehydrobromination, and demethoxycarbonylation, that is, a programmed aromatization.