1621223-57-1

Basic information

• Product Name: 1-(3,3-difluorocyclobutyl)ethan-1-one
• Synonyms: 1-(3,3-difluorocyclobutyl)ethan-1-one
• CAS NO: 1621223-57-1
• Molecular Formula: C6H8F2O
• Molecular Weight: 134.1239264
• Mol File: 1621223-57-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3,3-difluorocyclobutyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,3-difluorocyclobutyl)ethan-1-one(1621223-57-1)
• EPA Substance Registry System: 1-(3,3-difluorocyclobutyl)ethan-1-one(1621223-57-1)

Safety Data

• Hazardous Substances Data: 1621223-57-1(Hazardous Substances Data)

Usage

General Description

1-(3,3-difluorocyclobutyl)ethan-1-one, also known as DFEK, is a chemical compound with the molecular formula C6H8F2O. It is a fluoro-substituted cyclobutyl ketone, consisting of a four-membered cyclobutyl ring with two fluorine atoms attached to one of the carbon atoms and an ethanone group attached to another. DFEK is used in the pharmaceutical and agrochemical industries as an intermediate for the synthesis of various compounds. It is also utilized in research and development for its unique chemical properties and potential applications in drug discovery. DFEK is a colorless liquid with a molecular weight of 130.12 g/mol and a boiling point of 47-49°C. It is important to handle and store DFEK with caution due to its flammability and potential health hazards.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 107496-54-8 3,3-difluorocyclobutanecarboxylic acid 
• 681128-38-1 ethyl 3,3-difluorocyclobutane-1-carboxylate 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 87121-89-9 ethyl 3-oxocyclobutanecarboxylate 
• 676-58-4 methylmagnesium chloride 

Relevant articles and documents

TGF-betaR1 inhibitor and application thereof

The invention belongs to the field of medical chemistry, and particularly relates to a compound serving as a TGF-betaR1 inhibitor and application of the compound. Specifically, the invention providesa compound shown as a formula I or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, a preparation method of the compounds, a pharmaceutical composition containing the compounds and application of the compounds or the composition to treatment and/or prevention of TGF-betaR1 related diseases, such as cancers, tissue hyperplasia diseases, fibrosis and inflammatory diseases. The compound provided by the invention shows significant inhibitory activity on TGF-betaR1 kinase, and is very expected to become a therapeutic agent for TGF-betaR1 related diseases.

Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.