1621252-67-2Relevant academic research and scientific papers
A benzyl carbazate-based fluorescent chemosensor for detecting Zn2+: Application to zebrafish
Kim, Sehoon,Lee, Hangyul,So, Haeri,Lee, Hyojin,Kim, Ki-Tae,Kim, Cheal
, (2020)
A benzyl carbazate-based fluorescent chemosensor BCS was designed and synthesized for detection of Zn2+ in aqueous media. BCS displayed a notable fluorescence increase with Zn2+. Detection limit (1.12 μM) of BCS for zinc ion was much lower than the standard of World Health Organization. BCS was used to analyze the amounts of Zn2+ in water samples. Importantly, sensor BCS could be used to image Zn2+ in zebrafish, and a fluorescent test strip of sensor BCS for detecting Zn2+ could be useful for practical purpose. Sensing process of Zn2+ by BCS was demonstrated by DFT calculations, based on an effect of chelation-enhanced fluorescence.
ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE
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Paragraph 0283; 0285; 0288, (2019/04/14)
Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight
Vanucci-Bacque, Corinne,Carayon, Chantal,Bernis, Corinne,Camare, Caroline,Negre-Salvayre, Anne,Bedos-Belval, Florence,Baltas, Michel
, p. 4269 - 4276 (2014/08/18)
A novel series of hydrazones derived from substituted benzaldehydes have been synthesized as potential antiatherogenic agents. Several methods were used for exploring their antioxidant and cytoprotective properties, such as their scavenging effect on 2,2-
