1621252-72-9Relevant academic research and scientific papers
A Simple Fluorescent Probe for Sensing pH and its Application in E. coli Cells
Chao, Jianbin,Wang, Xiaolu,Zhang, Yongbin,Huo, Fangjun,Yin, Caixia,Xu, Miao
, p. 619 - 626 (2019)
We designed and synthesized a simple fluorescent probe, (E)-2-(2-(3,4,5-Trimethoxybenzylidene)hydrazinyl) benzothiazole (probe), which could be applied to the detection of strongly acidic and alkaline pH in DMSO/water (1/4, v/v) system. It could be used to quantitatively detect strong acid in the range of 2.60–3.53 with a pKa of 2.78. Meanwhile, it also showed an excellent linear relationship between the fluorescence intensity and alkaline pH values over the range of 9.98–10.95 with a pKa of 9.32. The probe exhibited excellent properties to pH with high selectivity and sensitivity. The mechanism studies showed that the H+ binding with the N atom of benzothiazole moiety and hydrazine moiety in acid solution while the deprotonation of N atom in hydrazine group in basic environment. Importantly, the probe was successfully applied for imaging the strongly acidic and alkaline in E.coil cells.
Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight
Vanucci-Bacque, Corinne,Carayon, Chantal,Bernis, Corinne,Camare, Caroline,Negre-Salvayre, Anne,Bedos-Belval, Florence,Baltas, Michel
, p. 4269 - 4276 (2014/08/18)
A novel series of hydrazones derived from substituted benzaldehydes have been synthesized as potential antiatherogenic agents. Several methods were used for exploring their antioxidant and cytoprotective properties, such as their scavenging effect on 2,2-
