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1621318-23-7

N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide

    Cas No: 1621318-23-7

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  • 1621318-23-7 Structure

  • Basic information

    1. Product Name: N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide
    2. Synonyms: N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide
    3. CAS NO:1621318-23-7
    4. Molecular Formula:
    5. Molecular Weight: 652.817
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1621318-23-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide(1621318-23-7)
    11. EPA Substance Registry System: N1-[3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N5-(phenylmethyl)pentanediamide(1621318-23-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1621318-23-7(Hazardous Substances Data)

1621318-23-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1621318-23-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,1,3,1 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1621318-23:
(9*1)+(8*6)+(7*2)+(6*1)+(5*3)+(4*1)+(3*8)+(2*2)+(1*3)=127
127 % 10 = 7
So 1621318-23-7 is a valid CAS Registry Number.

1621318-23-7Downstream Products

1621318-23-7Relevant articles and documents

High affinity ligands and potent antagonists for the α1D- adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives

Romeo, Giuseppe,Salerno, Loredana,Pittalà, Valeria,Modica, Maria N.,Siracusa, Maria A.,Materia, Luisa,Buccioni, Michela,Marucci, Gabriella,Minneman, Kenneth P.

, p. 419 - 432 (2014)

A new series of high affinity ligands and antagonists for the α1D-adrenergic receptor (AR) has been discovered. New molecules present a [1]benzothieno[3,2-d]pyrimidin-2,4(1H,3H)-dione or a [1]benzothieno[3,2-d]pyrimidin-4(3H)-one scaffold and bear a 2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl moiety in the 3-position and various amide substituents in the 8-position. In binding assays at the three human cloned α1A-, α1B-, and α1D-AR subtypes, they showed high affinity values, particularly for the α1D-AR subtype. Compound 22 (RX18), N1-methyl-N 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3, 4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N1-(phenylmethyl) pentanediamide, was the most interesting in the series displaying very high affinity (pKi = 10.25) and potent antagonism (pKb = 9.15) when tested in a functional assay at the α1D-AR.

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