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1621326-07-5

C28H24OS is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1621326-07-5 Structure

  • Basic information

    1. Product Name: C28H24OS
    2. Synonyms: C28H24OS
    3. CAS NO:1621326-07-5
    4. Molecular Formula:
    5. Molecular Weight: 408.564
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1621326-07-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C28H24OS(CAS DataBase Reference)
    10. NIST Chemistry Reference: C28H24OS(1621326-07-5)
    11. EPA Substance Registry System: C28H24OS(1621326-07-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1621326-07-5(Hazardous Substances Data)

1621326-07-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1621326-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,1,3,2 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1621326-07:
(9*1)+(8*6)+(7*2)+(6*1)+(5*3)+(4*2)+(3*6)+(2*0)+(1*7)=125
125 % 10 = 5
So 1621326-07-5 is a valid CAS Registry Number.

1621326-07-5Relevant articles and documents

MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT

-

, (2016/04/26)

The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.

Evaluation of class i HDAC isoform selectivity of largazole analogues

Kim, Bumki,Park, Heekwang,Salvador, Lilibeth A.,Serrano, Patrick E.,Kwan, Jason C.,Zeller, Sabrina L.,Chen, Qi-Yin,Ryu, Soyoung,Liu, Yanxia,Byeon, Seongrim,Luesch, Hendrik,Hong, Jiyong

, p. 3728 - 3731 (2014/09/17)

Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor. The majority of largazole analogues to date have modified the thiazole-thiazoline and the warhead moiety. In order to elucidate class I-specific structure-activity relationships, a series of analogues with modifications in the valine or the linker region were prepared and evaluated for their class I isoform selectivity. The inhibition profile showed that the C2 position of largazole has an optimal steric requirement for efficient HDAC inhibition and that substitution of the trans-alkene in the linker with an aromatic group results in complete loss of activity. This data will aid the design of class I isoform selective HDAC inhibitors.

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