1621387-65-2Relevant articles and documents
Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained
Tzitzoglaki, Christina,Wright, Anna,Freudenberger, Kathrin,Hoffmann, Anja,Tietjen, Ian,Stylianakis, Ioannis,Kolarov, Felix,Fedida, David,Schmidtke, Michaela,Gauglitz, Günter,Cross, Timothy A.,Kolocouris, Antonios
, p. 1716 - 1733 (2017)
While aminoadamantanes are well-established inhibitors of the influenza A M2 proton channel, the mechanisms by which they are rendered ineffective against M2S31N are unclear. Solid state NMR, isothermal titration calorimetry, electrophysiology,
ANTIVIRAL COMPOUNDS
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Paragraph 00103; 00105, (2014/08/19)
Compounds useful for treating and preventing viral infections including influenza are disclosed. Methods of treating or preventing viral infections, including influenza A infections are disclosed.