1621388-47-3

Basic information

• Product Name: 2-(4-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)-N-(3-(trifluoromethyl) phenyl) acetamide
• Synonyms: 2-(4-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)-N-(3-(trifluoromethyl) phenyl) acetamide
• CAS NO: 1621388-47-3
• Molecular Weight: 469.469
• Mol File: 1621388-47-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)-N-(3-(trifluoromethyl) phenyl) acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)-N-(3-(trifluoromethyl) phenyl) acetamide(1621388-47-3)
• EPA Substance Registry System: 2-(4-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)piperazin-1-yl)-N-(3-(trifluoromethyl) phenyl) acetamide(1621388-47-3)

Safety Data

• Hazardous Substances Data: 1621388-47-3(Hazardous Substances Data)

Upstream product

• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 85-44-9 phthalic anhydride 
• 351-38-2 N-chloroacetyl-3-(trifluoromethyl)aniline 
• 1621388-35-9 3-methyl-6-(piperazin-1-yl)-1,2,4-triazolo[3,4-a]phthalazine 
• 67458-38-2 6-chloro-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine 
• 51935-42-3 1-chloro-4-hydrazinophthalazine 
• 4752-10-7 1,4-dichlorophthalazine 
• 98-16-8 3-trifluoromethylaniline 

Relevant articles and documents

Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives

Trying to develop potent and selective anticancer agents, two series of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives were designed and synthesized. Their antitumor activities were evaluated by MTT method against four selected human cancer cell lines (MGC-803, EC-9706, HeLa and MCF-7). Our results showed that compound 11h exhibited good anticancer activities compared to 5-fluorouracil against the four tested cell lines, with IC50 values ranging from 2.0 to 4.5 μM. Flow cytometry analysis indicated that compound 11h induced the cellular early apoptosis and cell cycle arrest at G2/M phase in EC-9706.