1621417-76-2

Basic information

• Product Name: C₁₄H₁₃NO₄S₂
• Synonyms: C₁₄H₁₃NO₄S₂
• CAS NO: 1621417-76-2
• Molecular Weight: 323.394
• Mol File: 1621417-76-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₃NO₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₃NO₄S₂(1621417-76-2)
• EPA Substance Registry System: C₁₄H₁₃NO₄S₂(1621417-76-2)

Safety Data

• Hazardous Substances Data: 1621417-76-2(Hazardous Substances Data)

Upstream product

• 1621417-74-0 C₁₁H₉NO₃S₂ 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1621417-95-5 5-[5-(4-methoxyphenyl)-3-naphthalen-2-yl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-92-2 5-[5-(2-hydroxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-93-3 5-[5-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-94-4 5-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-96-6 5-[5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-97-7 5-[5-(4-chlorophenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 
• 1621417-98-8 5-[5-(4-chlorophenyl)-3-naphthalen-2-yl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one 

Relevant articles and documents

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core linked by enamine group. The structure and purity of compounds were confirmed by analytical and spectral data including X-ray analysis. Target compounds were scree

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

A series of novel 4-thiazolidinone-pyrazoline conjugates have been synthesized and tested for anti-Trypanosoma brucei activity. Screening data allowed us to identify five thiazolidinone-pyrazoline hybrids, which possess promising trypanocidal activity, with IC50 ≤ 1.2 μM. The highest active thiazolidinone-pyrazoline conjugates 3c and 6b (IC values of 0.6 μM and 0.7 μM, respectively) were 6-times more potent antitrypanosomal agents than nifurtimox. In addition, these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox. SAR study included substituent variations at the pyrazoline moiety, modifications of N3 position of the thiazolidinone portion, elongation of the linker between the heterocycles, as well as rhodanine-isorhodanine isomerism. It was also shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity.