162147-12-8

Basic information

• Product Name: 2-bromo-5-isopropoxybenzaldehyde
• Synonyms: 2-bromo-5-isopropoxybenzaldehyde
• CAS NO: 162147-12-8
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.09714
• Mol File: 162147-12-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 305.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.391±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-bromo-5-isopropoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-isopropoxybenzaldehyde(162147-12-8)
• EPA Substance Registry System: 2-bromo-5-isopropoxybenzaldehyde(162147-12-8)

Safety Data

• Hazardous Substances Data: 162147-12-8(Hazardous Substances Data)

Usage

General Description

2-bromo-5-isopropoxybenzaldehyde is a chemical compound with the molecular formula C11H13BrO2. It is a brominated benzaldehyde derivative with an isopropoxy (2-propanoxy) substituent at the 5 position. 2-bromo-5-isopropoxybenzaldehyde is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a pale yellow solid with a strong aromatic odor and is primarily used in research and development applications. The presence of the bromine atom and the benzaldehyde group make 2-bromo-5-isopropoxybenzaldehyde a versatile building block for the synthesis of various complex organic molecules with potential applications in drug discovery and agricultural chemistry.

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 75792-33-5 3-isopropoxybenzaldehyde 

Downstream Products

• 78416-88-3 telitoxine 
• 1312673-51-0 (Z)-2-(benzyloxy)-4-(2-bromo-5-isopropoxystyryl)-1-isopropoxybenzene 
• 1312673-50-9 (E)-2-(benzyloxy)-4-(2-bromo-5-isopropoxystyryl)-1-isopropoxybenzene 
• 185310-19-4 Ethyl 4-acetoxy-8-bromo-5-isopropoxy-2-naphthoate 
• 162147-18-4 Ethyl 8-bromo-5-isopropoxy-4-methoxy-2-naphthoate 
• 162147-17-3 Ethyl 8-bromo-4-hydroxy-5-isopropoxy-2-naphthoate 
• 162147-13-9 (E)-4-(2'-Bromo-5'-isopropoxyphenyl)-3-ethoxycarbonyl-3-butenoic acid 
• 162147-22-0 tert-Butyl (E)-4-(2'-bromo-5'-isopropoxyphenyl)-3-ethoxycarbonyl-3-butenoate 

Relevant articles and documents

Divergent Total Syntheses to Azafluoranthene and Dehydroaporphine Alkaloids

Facile divergent total syntheses for azafluoranthene and dehydroaporphine alkaloids have been successfully developed. A common intermediate, a biarylsulfonamide-protected amino aldehyde, underwent either a cascade or a stepwise cyclization to furnish a tetracyclic skeleton related to the azafluoranthene alkaloids. Natural products, triclisine and telitoxine, were prepared to illustrate the use of this approach. Subsequent C-homologation of the aldehyde moiety on the same intermediate by means of a Wittig reaction allowed the synthesis of aporphine alkaloids, as exemplified by the preparation of dehydronornuciferine. This synthetic approach could be applicable to the syntheses of other azafluoranthene-related as well as aporphine-related alkaloids. Facile divergent syntheses for azafluoranthene and dehydroaporphine alkaloids are reported by using a biarylsulfonamide-protected amino aldehyde as a common intermediate. The natural azafluoranthenes, triclisine and telitoxine, and an aporphine alkaloid, dehydronornuciferine, were prepared to illustrate the use of this approach.

Biomimetic total synthesis of michellamines A-C

The biomimetic first total synthesis of michellamines A, B, and C (1a-c), naturally occurring quateraryl alkaloids with high anti-HIV activity, is described. Key precursors are the molecular "halves" of michellamines, the antimalarial naphthylisoquinoline