162150-31-4Relevant articles and documents
Protoberberines from Reissert-Compounds, IV. A Novel Synthesis of (+/-)-Alamaridine and (+/-)-epi-Alamaridine
Reimann, E.,Renz, H.
, p. 1397 - 1406 (1994)
A novel synthesis of 8-methylisoquinonaphthyridinium salts 7 is reported using the intramolecular cyclization of the 1-substituted isoquinolines 5 as the key step, which in turn are obtained by alkylation of the Reissert compound 1.The salts 7 can be reduced by NaBH4 yielding the 8α- and 8β-methylstereomers (+/-)-alamaridine and (+/-)-epi-alamaridine 9c and 11c, respectively. - Keywords.Reissert compounds; Intramolecular cyclization; 8-Methylisoquinonaphthyridinium chlorides; (+/-)-Alamaridine; (+/-)-epi-Alamaridine.