162155-18-2Relevant academic research and scientific papers
Arenesulfonylation of N-alkylanilines: reaction kinetics and mechanism
Kochetova,Kustova,Kuritsyn,Katushkin
, p. 999 - 1006 (2017)
Kinetic regularities of arenesulfonylation of N-alkylanilines in binary water-organic solvents of variable composition have been studied. The rate constants for these reactions increase with increasing the water content in a system. The steric factor has
Optimization of the synthesis conditions of products formed in arenesulfonylation of N-alkylated anilines
Kustova,Smirnova,Kochetova,Kalinina
, p. 1274 - 1278 (2014)
Fundamental kinetic aspects of the arenesulfonylation of N-alkylated anilines in aqueous-organic media, the nonaqueous component of which are alcohols, ethers, and acetonitrile were studied. It was shown that, with increasing fraction of water in the solv
Solvent effects in the arenesulfonylation of N-alkylanilines
Kustova,Kochetova,Kalinina
, p. 214 - 217 (2014)
The kinetics of arenesulfonylation of N-methyl- and N-ethylaniline with 3-nitro- and 4-methylbenzenesulfonyl chlorides in aqueous 1,4-dioxane have been studied. Comparison of the solvent effects on the reaction of N-alkylanilines with arenesulfonyl chlori
Synthesis and anticandidal activity of azole-containing sulfonamides
Qandil, Amjad M.,Hassan, Mohammad A.,Al-Shar'i, Nizar A.
experimental part, p. 99 - 112 (2009/04/03)
Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.
