162155-27-3Relevant articles and documents
Genetically encoded cleavable protein photo-cross-linker
Lin, Shixian,He, Dan,Long, Teng,Zhang, Shuai,Meng, Rong,Chen, Peng R.
, p. 11860 - 11863 (2014)
We have developed a genetically encoded, selenium-based cleavable photo-cross-linker that allows for the separation of bait and prey proteins after protein photo-cross-linking. We have further demonstrated the efficient capture of the in situ generated selenenic acid on the cleaved prey proteins. Our strategy involves tagging the selenenic acid with an alkyne-containing dimethoxyaniline molecule and subsequently labeling with an azide-bearing fluorophore or biotin probe. This cleavage-and-capture after protein photo-cross-linking strategy allows for the efficient capture of prey proteins that are readily accessible by two-dimensional gel-based proteomics and mass spectrometry analysis.
N-PIPERIDIN-4-YL DERIVATIVES
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Page/Page column 24-25, (2013/04/10)
The invention relates to a N-piperidin-4-yl derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same and to the use of said N-piperidin-4-yl derivatives for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, or for the treatment of uterine fibroids or other menstrual-related disorders.
Synthesis of substituted carbazoles, indoles, and dibenzofurans by vinylic to aryl palladium migration
Zhao, Jian,Larock, Richard C.
, p. 5340 - 5348 (2007/10/03)
Substituted carbazoles, indoles, and dibenzofurans are readily prepared in moderate to excellent yields by the palladium-catalyzed cross-coupling of alkynes and appropriately substituted aryl iodides. This process proceeds by carbopalladation of the alkyn