1621685-90-2Relevant academic research and scientific papers
Leukotriene A4 hydrolase and cyclooxygense double target inhibitors and use thereof
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Paragraph 0033; 0034; 0035; 0121; 0122; 0123, (2016/10/07)
The invention discloses a double-target inhibitor for leukotriene A4 hydrolase and cyclooxygenase as well as a purpose of the double-target inhibitor. The double-target inhibitor is a compound shown in a general formula (I), wherein X1 and X2 are respectively and independently separated into hydrogen, halogen, alkyl or alkoxy; Y represents hydrogen, hydroxyl, halogen or alkyl; Z represents substituent groups at the fourth position and/or the fifth position of a benzoyl core benzene ring, and respectively represents hydrogen, halogen, amino, alkyl acylamino, alkyl substituted amino, trifluoromethyl or carboxyl alkyl acylamino; n is 2 to 4. The compound can be used for preparing medicine for treating, preventing or inhibiting inflammation such as arthritis and rheumatoid arthritis.
De novo design of multitarget ligands with an iterative fragment-growing strategy
Shang, Erchang,Yuan, Yaxia,Chen, Xinyi,Liu, Ying,Pei, Jianfeng,Lai, Luhua
, p. 1235 - 1241 (2014/05/20)
The discovery of multitarget drugs has recently attracted much attention. Most of the reported multitarget ligands have been serendipitous discoveries. Although a few methods have been developed for rational multitarget drug discovery, there is a lack of
