1621689-03-9

Upstream product

• 19064-67-6 6-chloro-2H-pyridazin-3-one 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 

Downstream Products

• 1621689-04-0 3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)benzoic acid 
• 1621689-09-5 N-(1H-benzoimidazol-2-yl)-3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)benzamide 
• 1621689-08-4 3-[3-(6-hydroxymethylpyridin-3-yl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid methyl ester 
• 1621689-13-1 3-(4-methyl-6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoic acid methyl ester 
• 1622068-63-6 3-[3-(5-hydroxymethyl-pyridin-3-yl)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester 
• 1622068-66-9 3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester 
• 1622068-56-7 methyl 3-((3-(3-(bromomethyl)phenyl)-6-oxopyridazin-1(6H)-yl)methyl)benzoate 
• 1622069-40-2 potassium 3-{3-[4-(2-amino-benzoimidazol-1-yl)-3-hydroxy-butoxy]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoate 
• 1622068-87-4 3-[3-(2-oxiranyl-ethoxy)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester 
• 1622069-07-1 methyl 3-((3-(3-((2-amino-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)methyl)benzoate 
• 1622069-08-2 lithium 3-((3-(3-((2-amino-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)methyl)benzoate 
• 1622068-86-3 3-(3-but-3-enyloxy-6-oxo-6H-pyridazin-1-ylmethyl)-benzoic acid methyl ester 
• 1622068-55-6 3-[3-(3-hydroxymethyl-phenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester 
• 1622068-57-8 3-{3-[3-(2-hydroxy-ethyl)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester 

Relevant academic research and scientific papers

PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.

PYRIDAZINONE-AMIDES DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1, Ra, Rb and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.

MACROCYCLIC PYRIDAZINONE DERIVATIVES

The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.