162174-56-3

Basic information

• Product Name: methyl 2-acetyl-3-phenylpentanoate
• Synonyms: methyl 2-acetyl-3-phenylpentanoate
• CAS NO: 162174-56-3
• Molecular Weight: 234.295
• Mol File: 162174-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-acetyl-3-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-acetyl-3-phenylpentanoate(162174-56-3)
• EPA Substance Registry System: methyl 2-acetyl-3-phenylpentanoate(162174-56-3)

Safety Data

• Hazardous Substances Data: 162174-56-3(Hazardous Substances Data)

Upstream product

• 93-54-9 1-Phenyl-1-propanol 
• 105-45-3 acetoacetic acid methyl ester 
• 2114-36-5 1-bromopropylbenzene 

Downstream Products

• 162174-57-4 methyl 2-(α-ethylbenzyl)-5-hydroxy-3-oxo-5-phenyl-heptanoate 

Relevant articles and documents

A general and efficient iron-catalyzed benzylation of 1,3-dicarbonyl compounds

Various CH-acidic 1,3-dicarbonyl compounds and methyl 3-acetamidobut-2- enoate react with benzylic alcohols to give the corresponding 2-benzylated products in good to excellent yield. Typically, reactions proceed under mild conditions (50-80°C; air) in the presence of catalytic amounts of inexpensive iron chloride hexahydrate. The benzylation of 4-hydroxycoumarin gives the pharmaceutically interesting 4-hydroxy-3-(1-phenylethyl)-2H-chromen-2- ones. As an example the anticoagulant Phenprocoumon is prepared in one step from commercially available substrates in 94 % yield.