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1622-79-3

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Product FOB Price Min.Order Supply Ability Supplier
1-(4-FLUOROPHENYL)-4-(4-METHYLPIPERIDIN-1-YL)BUTAN-1-ONE HYDROCHLORIDE
Cas No: 1622-79-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
BLOOM TECH Advanced API/Technology support Melperone hydrochloride CAS 1622-79-3
Cas No: 1622-79-3
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
1622-79-3
Cas No: 1622-79-3
No Data No Data No Data Nanjing Chemlin Chemical Co., Ltd. Contact Supplier
Methylperone hydrochloride
Cas No: 1622-79-3
No Data No Data No Data Suzhou Health Chemicals Co., Ltd. Contact Supplier
1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride
Cas No: 1622-79-3
No Data No Data No Data Chemsigma International Co.,Ltd. Contact Supplier
1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride
Cas No: 1622-79-3
No Data No Data No Data Shanghai Run-Biotech Co., Ltd. Contact Supplier
1-Butanone,1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)
Cas No: 1622-79-3
No Data No Data No Data Antimex Chemical Limied Contact Supplier
1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride
Cas No: 1622-79-3
No Data No Data No Data SHANGHAI T&W PHARMACEUTICAL CO., LTD. Contact Supplier
1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride
Cas No: 1622-79-3
No Data No Data No Data LEAP CHEM Co., Ltd. Contact Supplier
1-Butanone,1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)
Cas No: 1622-79-3
No Data No Data No Data Chongqing Ihlen Biotechlogy Co.,Ltd Contact Supplier

1622-79-3 Usage

Chemical Properties

White Solid

Originator

Eunerpan,Nordmark,W. Germany,1965

Uses

Melperone hydrochloride is a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.

Uses

Melperone Hydrochloride is an atypical antipsychotic drug.

Manufacturing Process

A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.Yield 22.0 g (73% of theory). MP 209°C to 211°C.

Therapeutic Function

Neuroleptic

Biological Activity

Atypical neuroleptic; 5-HT 2A /D 2 receptor antagonist (K i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α 1 and α 2 receptors (K i values are 180 and 150 nM respectively).

Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. A neuroleptic drug used to treat anxiety and confusion. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl.
InChI:InChI=1/C15H21FN2O.ClH/c1-17-9-11-18(12-10-17)8-2-3-15(19)13-4-6-14(16)7-5-13;/h4-7H,2-3,8-12H2,1H3;1H

1622-79-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one,hydrochloride

1.2 Other means of identification

Product number -
Other names 8-pCPT-2-O-Me-cAMP-AM

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1622-79-3 SDS

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