1622221-54-8

Basic information

• Product Name: (E)-N-(tert-butyl)-3-tosylacrylamide
• Synonyms: (E)-N-(tert-butyl)-3-tosylacrylamide
• CAS NO: 1622221-54-8
• Molecular Weight: 281.376
• Mol File: 1622221-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(tert-butyl)-3-tosylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(tert-butyl)-3-tosylacrylamide(1622221-54-8)
• EPA Substance Registry System: (E)-N-(tert-butyl)-3-tosylacrylamide(1622221-54-8)

Safety Data

• Hazardous Substances Data: 1622221-54-8(Hazardous Substances Data)

Upstream product

• 107-58-4 N-tert-Butylacrylamide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Relevant articles and documents

Copper-catalyzed aerobic oxidative N-S bond functionalization for C-S bond formation: Regio- and stereoselective synthesis of sulfones and thioethers

A regio- and stereoselective synthesis of sulfones and thioethers by means of CuI-catalyzed aerobic oxidative N-S bond cleavage of sulfonyl hydrazides, followed by cross-coupling reactions with alkenes and aromatic compounds to form the C-sp-2-S bond, is described herein. N2 and H2O are the byproducts of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry. First cleave, then cross-couple: A direct Cu-catalyzed aerobic oxidative C-sp-2-H functionalization and C-S bond coupling reaction has been developed (see scheme). By slight modification of the additive, sulfonyl hydrazides could serve as sulfonation, sulfenation, or arylation reagents to undergo cross-coupling reactions with alkenes and (hetero)aromatic cycles, affording sulfones, thioethers, and biaryl compounds with high regio- and stereoselectivities (see scheme).