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DorsManin A, a naturally occurring chemical compound isolated from the marine sponge D. cavernosa, is a potent inhibitor of the enzyme phosphodiesterase-4 (PDE4). This enzyme plays a crucial role in regulating cyclic adenosine monophosphate (cAMP) levels in cells. By inhibiting PDE4, DorsManin A can increase cAMP levels, which has been associated with anti-inflammatory and anti-tumor properties. Although research on DorsManin A is still in its early stages, its potential therapeutic applications for inflammatory diseases and cancer have garnered significant interest within the scientific community.

162229-27-8

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162229-27-8 Usage

Uses

Used in Pharmaceutical Industry:
DorsManin A is used as an anti-inflammatory agent for its ability to increase cAMP levels, which can help reduce inflammation in various conditions.
DorsManin A is used as an anti-tumor agent for its potential to inhibit the growth and progression of tumors by modulating the cAMP signaling pathway.
Used in Drug Development:
DorsManin A is used as a lead compound in the development of new drugs targeting PDE4 for the treatment of inflammatory diseases and cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 162229-27-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,2,2 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 162229-27:
(8*1)+(7*6)+(6*2)+(5*2)+(4*2)+(3*9)+(2*2)+(1*7)=118
118 % 10 = 8
So 162229-27-8 is a valid CAS Registry Number.

162229-27-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Dorsmanin A

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162229-27-8 SDS

162229-27-8Upstream product

162229-27-8Downstream Products

162229-27-8Relevant academic research and scientific papers

Hemisynthesis and Spectroscopic Characterization of Three New Chalcone Derivatives from Dorstenia barteri

Ngameni, Bathelemy,Fotso, Ghislain Wabo,Ambassa, Pantaleon,Kamga, Justin,Dastan, Arif,Ngadjui, Bonaventure Tchaleu

, p. 241 - 247 (2017)

The hemisynthesis of three new chalcones, namely kenzanol, kelianol A, and kelianol B, from Dorstenia barteri (Moraceae) is described here for the first time. The synthetic pathways employed in this work involved the pyrolysis and catalytic hydrogenation of readily available and starting materials, 4-hydroxylonchocarpin and isobavachalcone, two major constituents of the herbaceous plant D. barteri. The structural elucidation of all the compounds was done by mass spectrometry, IR, UV, 1D and 2D NMR analysis, and also by comparison with previous reports.

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