162269-78-5

Basic information

• Product Name: 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene
• Synonyms: 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene
• CAS NO: 162269-78-5
• Molecular Formula: C₈H₈BrFO₂
• Molecular Weight: 235.0503232
• Mol File: 162269-78-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 236.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.500±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene(162269-78-5)
• EPA Substance Registry System: 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene(162269-78-5)

Safety Data

• Hazardous Substances Data: 162269-78-5(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-fluoro-2-(methoxymethoxy)benzene is an organic compound with the chemical formula C8H8BrFO2. It is a member of the bromofluorobenzene family and contains a bromine atom, a fluorine atom, and a methoxymethoxy group attached to a benzene ring. 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene is used in organic synthesis and chemical research as a building block for the production of pharmaceuticals, agrochemicals, and materials. It is a colorless, transparent liquid with a strong, sweet odor. 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene is known to be potentially harmful if swallowed, inhaled, or in contact with skin, and appropriate safety measures should be taken when handling this chemical.

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 147460-41-1 2-bromo-5-fluorophenol 

Downstream Products

• 1170264-39-7 1-but-1-ynyl-4-fluoro-2-methoxymethoxy-benzene 
• 1037831-19-8 4-fluoro-1-iodo-2-methoxymethoxy-benzene 

Relevant articles and documents

A study of enantioselective syntheses by Sharpless asymmetric oxidation for aryl sulfoxides containing oxygen groups at the ortho position

Abstract: While ortho-alkoxy aryl sulfoxides including various substituents were synthesized by Sharpless asymmetric oxidation reaction, we optimized the reaction conditions and screened better combination of starting materials to obtain high enantioselectivity. The result suggested new information that electron-withdrawing substituents on the aromatic ring have a strong influence upon enantioselectivity of the products. Also, several chiral ligands for Sharpless asymmetric oxidation reaction were evaluated to improve the enantioselectivity. Graphic abstract: High enantioselectivity of ortho-alkoxy aryl chiral sulfoxides have been achieved by Sharpless oxidation reaction using Ti(O-i-Pr)4 and diethyl tartrate under anhydrous condition. In particular, the enantioselctivity of products was influenced by electron-withdrawing substituents on the aromatic ring, such as nitro, ester and aldehyde groups.[Figure not available: see fulltext.]

An intra/intermolecular suzuki sequence to benzopyridyloxepines containing geometrically pure exocyclic tetrasubstituted alkenes

(Chemical Equation Presented) A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogues was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are1) a syn-stereoselective diboratio