162272-77-7

Basic information

• Product Name: 3-<4-(2-Hydroxyethyl)-phenylhydrazono>-5,6-dihydro-pyran-2(4H)-on
• CAS NO: 162272-77-7
• Molecular Weight: 248.282
• Mol File: 162272-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-<4-(2-Hydroxyethyl)-phenylhydrazono>-5,6-dihydro-pyran-2(4H)-on(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<4-(2-Hydroxyethyl)-phenylhydrazono>-5,6-dihydro-pyran-2(4H)-on(162272-77-7)
• EPA Substance Registry System: 3-<4-(2-Hydroxyethyl)-phenylhydrazono>-5,6-dihydro-pyran-2(4H)-on(162272-77-7)

Safety Data

• Hazardous Substances Data: 162272-77-7(Hazardous Substances Data)

Upstream product

• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 

Downstream Products

• 162272-87-9 2-Benzyl-6-(2-hydroxyethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-on 
• 162272-93-7 2-(2-Benzyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-6-yl)-ethanol 

Relevant articles and documents

Indoles, XII: β-Carbolines from lactones - Synthesis of ligands of the norharmane receptor

Starting from α-ethoxalyl-δ-valerolactone (1) 6-substituted β-carbolines were synthesized in 5 steps to enable investigations at the norharmane binding sites in rat liver and in pig brain. The Pd-catalyzed aromatization of N-benzyl-tetrahydro-β-carbolines with debenzylation was optimized with 5a → 6a and then used for the preparation of other derivatives. Additional hydrogenolyses occur with 5d,h. Bromination of 1a gives 6d which can be transferred to the radioligand 3H-norharmane.